NEW COMPOUNDS USED AS POTASSIUM CHANNEL OPENERS Russian patent published in 2022 - IPC C07D333/24 A61K31/381 A61P27/16 

Abstract RU 2779131 C2

FIELD: medicine.

SUBSTANCE: present invention relates to new compounds selected from the following group of compounds: (1R,2R,4S)-rel-N-(3-(pentafluorosulfanyl)benzyl)bicyclo[2.2.1]heptane-2-carboxamide; (1S,2S,4R)-N-(3-(pentafluorosulfanyl)benzyl)bicyclo[2.2.1]heptane-2-carboxamide; 5-chloro-N-(4-(pentafluorosulfanyl)benzyl)thiophene-2-carboxamide, and a pharmaceutical composition for the prevention or treatment of a disorder related to aberrant activity of potassium channels.

EFFECT: compounds can be used as a drug for the prevention or treatment of hearing loss of the inner ear after damage or loss of sensory hair cells in the cortical organ.

6 cl, 3 dwg

Similar patents RU2779131C2

Title Year Author Number
NEW COMPOUNDS USED AS POTASSIUM CHANNEL OPENERS 2018
  • Boes, Michael
RU2779111C2
NON-AQUEOUS GEL COMPOSITION 2021
  • Begerskhauzen, Ansgar
  • Libikh, Lena
  • Risher, Mattias
RU2822601C1
2-OXA-5-AZABICYCLO[2.2.1]HEPTANE-3-YL DERIVATIVES 2015
  • Chechere Dzhuzeppe
  • Gallej Guido
  • Khu Imin
  • Norkross Rodzher
  • Pfliger Filipp
  • Shen Khun
RU2697651C2
APOPTOSIS INDUCING AGENTS FOR TREATING CANCER, IMMUNE AND AUTOIMMUNE DISEASES 2011
  • Din Khun
  • Ehlmor Stiven
  • Kheksamer Laura
  • Kanzer Aaron R.
  • Park Cheol-Min
  • Sauehrs Ehndrju Dzh.
  • Sallivan Dzherard
  • Uehndt Majkl
RU2568611C2
CATHEPSIN CYSTEINE PROTEASE INHIBITORS 2014
  • Stachel Shon
  • Peuan Deniel V.
  • Li Tszin
  • Nanda Kausik
RU2692799C2
SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE DERIVATIVES OF PYRIMIDINES, COMPOSITIONS THEREOF AND METHODS OF TREATING USE THEREOF 2012
  • Delgado, Mercedes
  • Yoon, Won, Hyung
  • Tikhe, Jayashree
  • Satoh, Yoshitaka
  • Romanow, William, J.
  • Sloss, Marianne
  • Paisner, David, A.
  • Norris, Stephen
  • Nagy, Mark, A.
  • Moghaddam, Mehran, F.
  • Mccarrick, Meg
  • Lebrun, Laurie, Ann
  • Hilgraf, Robert
  • Erdman, Paul
  • Elsner, Jan
  • Bennett, Brydon, L.
RU2697712C2
DERIVANTS OF BICYCLO[2, 2, 1] HEPT-7-YLAMINE AND THEIR APPLICATIONS 2006
  • Finch Garri
  • Rehj Nikolas Charl'Z
  • Bull Richard Dzhejms
  • Van Nil Monik Bodil
  • Dzhenningz Ehndrju Stefen Robert
RU2442771C2
DERIVATIVES OF PYRAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND INTERMEDIATE COMPOUNDS OF SYNTHESIS 1993
  • Fransi Bart
  • P'Er Kazella
  • Kristian Konzhi
  • Serzh Martinez
  • Mjur'Ell' Rinal'Di
RU2119917C1
SUBSTITUTED DIAMINO-CARBOXAMIDE AND DIAMINO-CARBONITRILE PYRIMIDINE DERIVATIVES, THEIR COMPOSITIONS AND METHODS OF TREATMENT USING THEM 2012
  • Bennett Brajdon L.
  • Elsner Yan
  • Erdman Pol
  • Khilgraf Robert
  • Lebren Lori Enn
  • Makkarrik Meg
  • Mogkhaddam Mekhran F.
  • Nejdzhi Mark A.
  • Norris Stefan
  • Pejzner Devid A.
  • Sloss Meriann
  • Romanov Uilliam Dzh.
  • Satokh Jositaka
  • Tike Dzhejeshri
  • Joon Von Khiung
  • Delgado Mersedes
RU2625309C2
BORONIC ACID DERIVATIVES 2018
  • Klein Markus
  • Schadt Oliver
  • Esdar Christina
RU2793315C2

RU 2 779 131 C2

Authors

Bes, Mikhel

Dates

2022-09-01Published

2018-02-27Filed