FIELD: pharmacology.
SUBSTANCE: in formula (I)
,
R1 and R2 independently represent unsubstituted C1-8alkyl; C1-8alkyl substituted with one or more halogen atoms, hydroxy, C1-3alkoxy, C1-3alkoxy, C1-3alkyl, halogenC1-3alkoxy or hydroxyC1-3alkyl; unsubstituted saturated 3-7-membered monocycloalkyl or 5-8-membered bicycloalkyl; substituted saturated 3-7-membered monocycloalkyl or 5-8-membered bicycloalkyl, wherein the substituents are selected from halogen, C1-6alkyl, hydroxy, oxo, C1-3alkoxy, C1-3alkoxyC1-3alkyl, halogenC1-3alkyl, halogenC1-3alkoxy, hydroxyC1-3alkyl, aminoC1-3alkyl, O-cyclopropyl, NH2, NH(C1-3)alkyl, N(C1-3alkyl)2, C(O)-C1-3alkyl, NHC(O)-C1-3alkyl, C(O) NH2, C(O) NHC1-3alkyl, C(O)N(C1-3alkyl)2 and NHSO2(C1-3alkyl) and pyrrolidine; unsubstituted C1-3alkyl-C3-6cycloalkyl; 4-6-membered nonaromatic monocyclic heterocyclyl, optionally N-substituted with group of C1-3alkyl-C(O) or optionally substituted with C1-3alkyl, oxo or hydroxy, wherein heteroatoms are selected from 1-2 oxygen atoms or 1 nitrogen atom, or dioxaspirodecanyl.
EFFECT: compounds can be used for the treatment or prevention of fibrotic liver diseases or metabolic syndrome, which lead to the development of fibrotic liver diseases such as: nonalcoholic steatohepatitis, steatosis, cirrhosis, primary sclerosing cholangitis, primary biliary cirrhosis, hepatitis, hepatocellular carcinoma or liver fibrosis, connected with chronic or recurrent alcohol consumption, infection, liver transplantation or liver injury caused by taking drugs, and as well as for treatment or prevention of interstitial pulmonary fibrosis.
67 cl, 3 tbl, 62 ex
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