ANTIBODIES SPECIFIC TO CD47 AND PD-L1 Russian patent published in 2022 - IPC C07K16/28 C07K16/46 C12N15/13 C12N15/63 A61K39/395 A61P35/00 

Abstract RU 2779652 C2

FIELD: biotechnology.

SUBSTANCE: bispecific antibody is proposed, which specifically binds to CD47 and PD-L1. The invention also relates to nucleic acid encoding this antibody, an expression vector, a method for the production of an antibody, and to the use of antibodies and compositions including the specified antibodies in cancer therapy.

EFFECT: invention provides for specific high-affine binding of CD47 and PD-L1 and reduction in undesired effects.

23 cl, 17 dwg, 11 tbl, 23 ex

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Authors

Solovev Kirill Vladimirovich

Ulitin Andrej Borisovich

Nemankin Timofej Aleksandrovich

Solovev Valerij Vladimirovich

Morozov Dmitrij Valentinovich

Dates

2022-09-12Published

2020-04-29Filed