FIELD: biotechnology.
SUBSTANCE: bispecific antibody is proposed, which specifically binds to CD47 and PD-L1. The invention also relates to nucleic acid encoding this antibody, an expression vector, a method for the production of an antibody, and to the use of antibodies and compositions including the specified antibodies in cancer therapy.
EFFECT: invention provides for specific high-affine binding of CD47 and PD-L1 and reduction in undesired effects.
23 cl, 17 dwg, 11 tbl, 23 ex
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