FIELD: medicine.
SUBSTANCE: disclosed are polypeptides for treating a disease associated with SIRPα activity or CD47, nucleic acids encoding polypeptides, vectors and a host cell containing a nucleic acid. Disclosed are methods of producing a polypeptide for treating a disease associated with SIRPα activity or CD47, including culturing a host cell and methods of treating cancer in a subject. Disclosed are dimers for treating a disease associated with SIRPα activity or CD47 containing a polypeptide. Disclosed are pharmaceutical compositions for treating a disease associated with SIRPα activity or CD47, containing polypeptide or dimer and pharmaceutically acceptable excipient.
EFFECT: presented group of inventions provides effective cancer treatment methods and their applications.
73 cl, 20 dwg, 28 tbl, 20 ex
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