FIELD: biotechnology.
SUBSTANCE: isolated monoclonal antibodies, which specifically bind to EGFL6, and conjugates including them are proposed. Nucleic acids, expression vectors, and host cells for the production of the specified antibodies are also proposed. Antibodies, according to the invention, can be used for the detection or therapeutic treatment of EGFL6-positive malignant tumor.
EFFECT: invention provides for high affinity of binding and effective inhibition of EGFL6 activity and cancer cell growth.
38 cl, 12 dwg, 3 tbl, 9 ex
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