FIELD: biotechnology.
SUBSTANCE: invention relates to an isolated antibody or its antigen-binding fragment, which specifically bind α vβ 8 integrin, the method of its preparation, as well as compositions and kits containing it. An isolated nucleic acid that encodes the amino acid sequences of an antibody or an antigen-binding fragment thereof, as well as a vector and a cell containing it, are also disclosed. The invention also relates to a method of reducing activity of α vβ 8 integrin in the subject, as well as the method of determination ofα vβ 8 integrin in a sample, tissue or cell containing the above antibody or a fragment thereof.
EFFECT: invention is effective for treatment or prevention of cancer or a condition mediated by the activity ofα vβ 8 integrin.
51 cl, 31 dwg, 19 tbl, 26 ex
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