METHODS FOR TREATMENT OF GAUCHER DISEASE Russian patent published in 2022 - IPC A61K31/4025 A61P3/00 A61P1/16 A61P13/12 

FIELD: medicine.

SUBSTANCE: methods for the treatment of Gaucher disease in a patient, which is a fast CYP2D6 metabolizer with light hepatic insufficiency or with moderate or severe renal insufficiency, are proposed. The use of a composition containing a dose of 84 mg of eliglustat or its pharmaceutically acceptable salt per the main form is proposed for administration once a day for the treatment of Gaucher disease in a patient who needs it, in a combination with a weak CYP2D6 inhibitor or with a strong, moderate, or weak CYP3A inhibitor. The use of a composition containing a dose of 84 mg of eliglustat or its pharmaceutically acceptable salt per the main form is proposed for administration twice a day for the treatment of Gaucher disease in a patient, where the patient is a fast CYP2D6 metabolizer with light hepatic insufficiency or with moderate or severe renal insufficiency.

EFFECT: proposed group of inventions provides safe use of eliglustat for the treatment of Gaucher disease in patients with hepatic or renal insufficiency.

9 cl, 6 dwg, 4 tbl, 3 ex