GENOTYPE- OR PHENOTYPE-BASED DRUG FORMULATION Russian patent published in 2019 - IPC A61K45/06 A61K31/138 A61P35/00 

Abstract RU 2683260 C2

FIELD: medicine.

SUBSTANCE: invention relates to a composition for treating breast cancer, wherein the composition contains tamoxifen and at least its metabolite endoxifene. This composition contains 15–25 mg of tamoxifen and 0.25–5.0 mg of endoxifen, while the dosage of tamoxifen and endoxifen is chosen based on the expression of CYP2D6 in patients undergoing treatment.

EFFECT: implementation of the invention allows to ensure a rapid achievement of the effect level of endoxifen and tamoxifen in plasma in patients with IM and PM.

3 cl, 18 dwg

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RU 2 683 260 C2

Authors

Villmann Shtefan

Ajssing Tomas

Dikshen Kristin

Dates

2019-03-27Published

2013-05-27Filed