METHODS AND COMPOSITIONS FOR DELIVERY OF ARYLSULFATASE A TO CNS Russian patent published in 2022 - IPC A61K38/47 A61K38/46 A61K47/02 A61K47/26 A61K9/08 A61P25/00 

FIELD: pharmaceutical industry.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, namely to the use of a composition containing protein arylsulfatase A (hereinafter – ASA) for the manufacture of a drug for the treatment of metachromatic leukodystrophy (hereinafter – MLD). The use of a composition containing protein ASA is proposed for the manufacture of a drug for the treatment of MLD, wherein the specified protein ASA is present in the composition at a concentration from at least 5 to 50 mg/ml, while the specified composition contains phosphate in amount of no more 10 mM, while the specified composition is administered intracerebroventricular (hereinafter – ICV). The use of a composition containing protein ASA and pharmaceutically acceptable auxiliary substance is also proposed for the manufacture of a drug for the treatment of MLD, wherein the specified protein ASA is present in the composition at a concentration of 30 mg/ml, while the specified composition contains NaCl at a concentration of 154 mM, polysorbate 20 at a concentration of 0.005% vol./vol. and has pH of 6.0, while the specified composition is administered ICV.

EFFECT: above-described agents are effective for the manufacture of a drug for the treatment of MLD in intracerebroventricular administration.

28 cl, 56 dwg, 46 tbl, 9 ex