FIELD: medicine.
SUBSTANCE: claimed invention discloses the use of haptoglobin for the treatment or prevention of an adverse secondary neurological outcome in a subject following a haemorrhagic stroke, accompanied by extravascular erythrolysis and release of cell-free hemoglobin into cerebrospinal fluid (CSF), comprising exposing the CSF of a subject in need thereof to a therapeutically effective amount of haptoglobin and for a period of time, sufficient to allow haptoglobin to form a complex with cell-free hemoglobin and thereby neutralize it.
EFFECT: treating or preventing an adverse secondary neurological outcome in a subject following a haemorrhagic stroke.
15 cl, 19 dwg
| Title |
Year |
Author |
Number |
| SYSTEM OF INTRAVENTRICULAR DRUG DELIVERY TO IMPROVE OUTCOME AFTER BRAIN DAMAGE, VIOLATING CEREBRAL BLOOD CIRCULATION |
2012 |
- Makdonald R. Lok
- Lejtner Brajan A.
|
RU2606169C2 |
| SHORT-TERM ACTING DIHYDROPYRIDINES (CLEVIDIPINE) FOR RECOVERY AFTER STROKE |
2012 |
|
RU2623039C2 |
| COMPOSITIONS AND METHODS FOR IMPROVEMENT OF FORECAST OF PERSON WITH SUBARACHNOIDAL HEMORRHAGE |
2012 |
- Lejtner Brajan A.
- Makdonald Lok R.
|
RU2597791C2 |
| METHODS AND FORMULATIONS FOR TREATING SUBARACHNOIDAL HAEMORRHAGE OF CORONARY AND ARTERIAL ANEURISM |
2009 |
- Sammar Marshal L.
- Bar Friderik E.
- Tompson Rejd Karleton
|
RU2528097C2 |
| APPLICATION OF COMPOUNDS FOR PRODUCING MEDICINAL PRODUCT FOR TREATING HEMORRHAGIC STROKE |
2018 |
- Yan, Guanmej
- Khuan, Itszyun
- In, Vej
- Lin, Sujchzhen
|
RU2752090C1 |
| HAEMOGLOBIN COMPOSITION |
2010 |
- Abuchovski Abrakham
- Sloshberg Stiven
- O'Kher Kit
|
RU2589254C2 |
| HYBRID PROTEIN IGF-1-LONG FOR TREATING STROKE, NUCLEIC ACID, VECTOR, CELL, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT |
2018 |
- Dukhovlinov Ilya Vladimirovich
|
RU2711111C1 |
| IMATINIB FOR USE IN TREATMENT OF STROKE |
2017 |
- Eriksson, Ulf
- Valgren, Nils Gunnar
|
RU2739382C1 |
| GOLD CLUSTERS, COMPOSITIONS AND METHODS OF TREATING CEREBRAL STROKE |
2021 |
|
RU2822217C1 |
| COMPOSITIONS AND METHODS FOR TREATING NON-ACUTE PERIODS FOLLOWING NEUROLOGICAL DAMAGE |
2009 |
- Kadzhano Ehntoni
- Ajasi Dzhennifer
|
RU2501564C2 |
