COMBINATION THERAPY USING DIARYL MACROCYCLIC COMPOUNDS Russian patent published in 2022 - IPC A61K31/439 A61K31/4995 A61P35/00 C07D498/18 

Abstract RU 2784853 C2

FIELD: medicine.

SUBSTANCE: present invention relates to a method for the treatment of cancer in a patient who needs treatment. The method includes administration to the patient of therapeutically effective amount of a compound having the formula or its pharmaceutically acceptable salt in a combination with therapeutically effective amount of EGFR inhibitor or its pharmaceutically acceptable salt, where EGFR inhibitor is Osimertinib or its pharmaceutically acceptable salt, and where cancer is lung cancer.

EFFECT: invention provides a synergetic response in a patient who needs treatment of cancer.

11 cl, 20 dwg, 2 tbl, 6 ex

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RU 2 784 853 C2

Authors

Cui, Jingrong, Jean

Zhai, Dayong

Dates

2022-11-30Published

2018-01-25Filed