FIELD: chemistry.
SUBSTANCE: invention relates to a method for synthesising 6-aminocaproic acid applied in therapeutic and surgical practice as an antifibrinolytic. Method involves subjecting ε-caprolactam to hydrolysis with hydrohalic acid, resulting in onium salt of 6-aminocaproic acid; mixing the onium salt of 6-aminocaproic acid with an organic base in a solvent medium; and isolating the 6-aminocaproic acid. The method is characterised by distilling excess hydrohalic acid and water after the stage of hydrolysis of ε-caprolactam, until a technical mixture is formed, containing 6-aminocaproic acid, hydrohalic acid, and water; and using amines with a pKa value of the corresponding conjugated acids of more than 7.59 as an organic base.
EFFECT: proposed method allows for a reduction in the duration of the process and increase in the output of the target product.
3 cl, 10 ex
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