FIELD: veterinary medicine.
SUBSTANCE: vaccine composition for immunization and/or protection of a mammal – a dog, a cat, or a horse – from a disease mediated by IL-31 is proposed, where the specified composition contains a combination of a polypeptide carrier and at least one mimotope of peptide IL-31, and an adjuvant. Mimotope of peptide IL-31 has a length from about 5 to about 40 amino acids, and it is selected from a group consisting of mimotope of dog IL-31, mimotope of cat IL-31, mimotope of horse IL-31, and mimotope of human IL-31. A method for protection of a mammal from a disease mediated by IL-31 is presented. The method includes administration to a mammal of the presented vaccine composition.
EFFECT: invention allows for obtaining a vaccine for reduction in skin itch and skin damage in dogs, cats, horses with atopic dermatitis.
20 cl, 39 dwg, 2 ex
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