FIELD: medicine.
SUBSTANCE: present invention relates to an anti-CD19 antibody or its antigen-binding fragment, an isolated polynucleotide sequence encoding them, an expression vector containing the isolated polynucleotide, a host cell for obtaining an antibody or its antigen-binding fragment, a method for expressing an antibody or its antigen-binding fragment, an antibody-drug conjugate, a pharmaceutical composition for the treatment of a CD19-bound disease or condition, a method for treating a CD19-related disease or pathological condition, a chimeric antigenic receptor, a nucleic acid sequence molecule, an expression vector containing a nucleic acid sequence, an isolated T cell, a method for stimulating the T cell immune response, a kit for detecting the presence or amount of CD19 in a sample or for diagnosing a CD19-related disease or condition in an individual.
EFFECT: expansion of the range of solutions for treating CD19.
19 cl, 7 ex, 14 dwg, 14 tbl
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