DERIVATIVE OF 6-OXO-1,6-DIHYDROPYRIDAZINE, METHOD FOR PRODUCTION THEREOF AND APPLICATION THEREOF IN MEDICINE Russian patent published in 2023 - IPC C07D237/22 C07D237/20 A61K31/50 A61P29/00 

FIELD: pharmaceuticals.

SUBSTANCE: group of inventions relates to pharmaceutical chemistry and includes a derivative of 6-oxo-1,6-dihydropyridazine by the formula (I), intermediates by the formulas (IA) and (IB) for producing a compound by the formula (I), methods for producing a compound by the formula (I), a pharmaceutical composition containing a compound by the formula (I), and an application of the compound by the formula (I). In formula (I), M is selected from the group consisting of an atom of O, CH₂, and S; the ring A constitutes a 6-10-membered aryl or ; all R¹ are the same or different, and each is independently selected from the group consisting of an atom of hydrogen, a halogen, a C_1-6 alkyl, a C_1-6 alkoxy, a halogen-C_1-6 alkyl and halogen-C_1-6 alkoxy; all R² are the same or different, and each is independently selected from the group consisting of an atom of hydrogen, a halogen, a C_1-6 alkyl, a C_1-6 alkoxy, a deuterated C_1-6 alkyl, a deuterated C_1-6 alkoxy, a halogen-C_1-6 alkyl, a halogen-C_1-6 alkoxy, a hydroxy, a C_3-6 cycloalkyl, and a C_3-6 cycloalkyloxy; all R³ constitute an atom of hydrogen; n and s equal 0, 1, 2, 3, or 4; and t equals 0, 1, or 2.

EFFECT: derivative of 6-oxo-1,6-dihydropyridazine by the formula (I), exhibiting the properties of an inhibitor of potential-dependent sodium channels (Na_V).

,

18 cl, 4 tbl, 48 ex