TRICYCLIC TETRAHYDROISOQUINOLINE DERIVATIVE, METHOD FOR PRODUCTION THEREOF AND USE THEREOF IN MEDICINE Russian patent published in 2024 - IPC C07D491/56 C07F7/18 A61K31/4741 A61K31/695 A61P3/00 A61P5/30 A61P7/00 A61P9/00 A61P15/00 A61P25/28 A61P31/00 A61P35/00 A61P37/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of general formula (I) or its mesomer, racemate, enantiomer or diastereomer or mixture thereof, or its pharmaceutically acceptable salt, which have the ability to modulate oestrogen receptors. In formula (I), R^1a and R^1b are identical or different and each is independently selected from the group consisting of a H atom, a deuterium atom, a halogen and a C_1-6alkyl; ring A is 4–5 membered heterocyclyl containing 1 heteroatom selected from N; Z is selected from a group consisting of an O atom and NR⁷; all G¹, G², G³ and G⁴ are CR⁸ or one of G¹, G², G³ and G⁴ is a N atom, and the remaining ones are CR⁸; R² is a hydrogen atom; R³ is a hydrogen atom; R⁴ is C_1-6alkyl; R⁵ is C_1-6alkyl, where said C_1-6alkyl is substituted with one or more substitutes selected from the group consisting of halogen, hydroxy and C_1-6hydroxyalkyl; R⁶ are identical or different and each is independently selected from the group consisting of a hydrogen atom and C_1-6haloalkyl; R⁷ is a hydrogen atom; R⁸ are identical or different and each is independently selected from the group consisting of a hydrogen atom and a halogen; n is 1 or 2; s is 0, 1 or 2 and p is 0, 1 or 2. Invention also relates to methods of producing a compound of formula (I), intermediate compounds, a pharmaceutical composition containing a compound of general formula (I), and embodiments of its use for preventing and/or treating a disease or condition mediated by or dependent on an oestrogen receptor.

EFFECT: compounds can be used to prevent and/or treat a disease or condition mediated by an oestrogen receptor or dependent on it.

40 cl, 9 tbl, 21 ex