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(19)

RU

(11)

2 798 285

(13)

C2

(51)

IPC

C07K16/28(2006-01-01)

C12N15/13(2006-01-01)

C12N15/63(2006-01-01)

C07K19/00(2006-01-01)

A61K39/395(2006-01-01)

A61P35/00(2006-01-01)

A61K47/68(2017-01-01)

(21) (22)

Application

2019141268, 2018-05-14

(24)

Start date

2018-05-14

(22)

Actual filing date

2018-05-14

(45)

Published

2023-06-21

(72)

Inventor

Saito AtsukoHirata TsuyoshiNakamura Kensuke

(73)

Holder

Daiichi Sankyo Company, Limited

ANTI-CDH6-ANTIBODY AND ANTI-CDH6-ANTIBODY-DRUG CONJUGATE Russian patent published in 2023 - IPC C07K16/28 C12N15/13 C12N15/63 C07K19/00 A61K39/395 A61P35/00 A61K47/68 

Abstract RU 2798285 C2

FIELD: biotechnology.

SUBSTANCE: antibody is proposed that binds to CDH6 and has the ability to internalize. Also conjugates of the specified antibody and a drug that have antitumor activity are proposed. In addition, the invention relates to pharmaceutical compositions containing an antibody-drug conjugate used to treat or diagnose a tumor, a method of treating a tumor using an antibody-drug conjugate, or a pharmaceutical composition.

EFFECT: increased ability of the antibody to internalize into cells expressing CDH6, which allows its use as an antibody for ADC.

59 cl, 29 dwg, 16 tbl, 9 ex

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RU 2 798 285 C2

Authors

Saito Atsuko

Hirata Tsuyoshi

Nakamura Kensuke

Dates

2023-06-21—Published

2018-05-14—Filed

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