FIELD: biotechnology.
SUBSTANCE: invention relates to a caninized antibody, including a crystallizable fragment region (cFc region), a hinge region and a combination of complementary determined regions (CDR) of heavy and light chains, as well as to a composition containing it. Also a nucleic acid encoding the heavy chain and the light chain of the above antibody, as well as a vector containing it are provided.
EFFECT: invention is effective for the treatment of PD-1 mediated diseases.
10 cl, 10 dwg, 14 tbl, 5 ex
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