FIELD: biotechnology.
SUBSTANCE: invention relates to a caninized antibody, including a crystallizable fragment region (cFc region), a hinge region and a combination of complementary determined regions (CDR) of heavy and light chains, as well as to a composition containing it. Also a nucleic acid encoding the heavy chain and the light chain of the above antibody, as well as a vector containing it are provided.
EFFECT: invention is effective for the treatment of PD-1 mediated diseases.
10 cl, 10 dwg, 14 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DOG ANTIBODIES WITH MODIFIED CH-CH SEQUENCES | 2014 |
|
RU2815059C2 |
| CANINIZED ANTI-HUMAN CTLA-4 ANTIBODIES | 2020 |
|
RU2822460C2 |
| ANTI-CANINE CTLA-4 ANTIBODY | 2020 |
|
RU2818586C2 |
| ANTI-IL31 ANTIBODIES FOR VETERINARY USE | 2018 |
|
RU2795485C2 |
| ANTIBODIES TO DOGS' PD-1 | 2014 |
|
RU2732604C2 |
| PD-L1 ANTIBODIES BINDING DOG PD-L1 | 2015 |
|
RU2722562C2 |
| MONOCLONAL ANTIBODIES TO INTERLEUKIN-31 FOR VETERINARY USE | 2019 |
|
RU2795411C2 |
| PEPTIDE VACCINES AGAINST INTERLEUKIN-31 | 2019 |
|
RU2786441C2 |
| IL4/IL13 RECEPTOR MOLECULE FOR VETERINARY USE | 2018 |
|
RU2795591C2 |
| EMBODIMENTS OF IGG-Fc FOR USE IN VETERINARY SCIENCE | 2018 |
|
RU2814952C2 |
