Patenton — panteon of patents

(19)

RU

(11)

2 802 825

(13)

C2

(51)

IPC

C07K14/08(2006-01-01)

C07K14/705(2006-01-01)

A61K39/12(2006-01-01)

C12N15/62(2006-01-01)

C12N15/63(2006-01-01)

C12N7/01(2006-01-01)

A61P31/14(2006-01-01)

(21) (22)

Application

2021139955, 2021-12-30

(24)

Start date

2021-12-30

(22)

Actual filing date

2021-12-30

(45)

Published

2023-09-04

(72)

Inventor

Isaev Artur AleksandrovichKudryavtsev Aleksandr ViktorovichFrolova Mariya EvgenevnaVakhrusheva Anna VladimirovnaIvanov Aleksandr ViktorovichDzhonovich MilanaIvanishin Taras VladimirovichKrasilnikov Igor Viktorovich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennostyu

GENE CONSTRUCT FOR THE EXPRESSION OF RECOMBINANT PROTEINS BASED ON THE SEGMENT OF THE SARS-COV-2 S-PROTEIN, INCLUDING RBD AND SD1, FUSED WITH THE FC FRAGMENT OF IGG, A METHOD OF OBTAINING RECOMBINANT PROTEINS, ANTIGENS AND ANTIGENIC COMPOSITIONS FOR THE INDUCTION OF LONG-TERM ANTIBODY AND CELLULAR IMMUNITY AGAINST SARS-CO-2 Russian patent published in 2023 - IPC C07K14/08 C07K14/705 A61K39/12 C12N15/62 C12N15/63 C12N7/01 A61P31/14 

Abstract RU 2802825 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to a gene construct for the expression of a recombinant protein, including a portion of the S-protein of the SARS-CoV-2 virus, consisting of amino acid residues 302-638 of the RBD and SD1 domains, fused to the Fc fragment of IgG through a polyglycine-serine linker including an expression cassette, as well as to a method of producing an antigen for inducing immunity against the SARS-CoV-2 virus using it. Also an antigen for inducing immunity against the SARS-CoV-2 virus, as well as an antigenic composition containing it are disclosed.

EFFECT: invention is effective for inducing an immune response against SARS-CoV-2 virus.

22 cl, 17 dwg, 4 tbl

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RU 2 802 825 C2

Authors

Isaev Artur Aleksandrovich

Kudryavtsev Aleksandr Viktorovich

Frolova Mariya Evgenevna

Vakhrusheva Anna Vladimirovna

Ivanov Aleksandr Viktorovich

Dzhonovich Milana

Ivanishin Taras Vladimirovich

Krasilnikov Igor Viktorovich

Dates

2023-09-04—Published

2021-12-30—Filed

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