ANTIBODIES TO B7-H1 AND CTLA-4 FOR THE TREATMENT OF NON-SMALL CELL LUNG CANCER Russian patent published in 2023 - IPC A61K39/395 A61P35/00 

Abstract RU 2806210 C2

FIELD: pharmaceuticals.

SUBSTANCE: method for treating non-small-cell lung cancer (NSCLC) in a patient, including the administration of MEDI4736 and tremelimumab, where (i) the administration can give an average Cmax with a value of 266-300 μg/ml MEDI4736 and Cmax with a value of 25-30 μg/ml tremelimumab; (ii) MEDI4736 is administered 1 hour after tremelimumab administration and (iii) MEDI4736 and tremelimumab are administered every 4 weeks for a maximum of 16 weeks.

EFFECT: safety and synergistic effectiveness of the combination.

9 cl, 37 dwg, 9 tbl, 9 ex

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RU 2 806 210 C2

Authors

Narwal, Rajesh

Robbins, Paul

Karakunnel, Joyson

Dar, Mohammed M.

Dates

2023-10-30Published

2015-05-12Filed