METHOD OF TREATING PATIENTS WITH SEVERE FORMS OF REPERFUSION SYNDROME Russian patent published in 2023 - IPC A61K31/702 A61K31/351 A61K31/616 A61K31/5375 A61K31/4365 A61K31/727 A61K35/16 A61K31/4415 A61K31/51 A61K31/714 A61P43/00 

FIELD: medicine.

SUBSTANCE: invention can be used in the treatment of patients with severe forms of reperfusion syndrome after reconstructive surgical interventions on the arteries of the lower extremities. The treatment is carried out in three stages: at the first stage of treatment, a plasmapheresis session is used for 10 days. Next, Longidaza 3,000 IU is administered, it is dissolved in 1.0–2.0 ml of 0.5% Novocaine solution and injected in the first interdigital space once, Phlebodia 600 mg 2 tablets in the morning orally, Clopidogrel 75 mg per day, ThromboAss 100 mg per day, Rivaroxaban 2.5 mg 2 times a day orally, Sulodexide 600 LE intravenous drip and Actovegin 10 ml intravenous drip, Neuromultivit 2 ml intramuscularly once a day, class 2 elastic compression of the lower extremities — elastic stockings, individually selected in size or elastic bandages and elevated position of the limb on a splint. At the second stage of treatment lasting 10 days, elastic compression of the lower extremities of class 2 is still used, and the following medicinal products are used: ThromboAss 100 mg per day, Clopidogrel 75 mg 1 tablet once a day, Rivaroxaban 2.5 mg 1 tablet 2 times a day, Phlebodia 600 mg 1 tablet 1 time a day in the morning, Sulodexide 600 LE intramuscularly once a day, Neuromultivit 1 tablet 3 times a day, Actovegin 5 ml intramuscularly 1 time a day. At the third stage, elastic compression of the lower extremities of class 2 is still used, and the following disaggregants are used: ThromboAss 100 mg 1 tablet once a day, Clopidogrel 75 mg 1 tablet once a day, Rivaroxaban 2.5 mg 1 tablet 2 times a day for 12 months, Phlebodia 600 mg 1 tablet once a day in the morning for 3 months, Sulodexide 250 LE 1 capsule 2 times a day orally for 2 months, Neuromultivitis 1 tablet 3 times a day orally for 1 month, Actovegin 2 capsules 3 times a day orally for 4 months.

EFFECT: invention makes it possible to reduce or completely eliminate reperfusion edema of the operated lower limb and shorten the treatment time.

1 cl, 2 ex