NEW PYRIMIDINE DERIVATIVE SUBSTITUTED WITH DEUTERIUM AND PHARMACEUTICAL COMPOSITION CONTAINING IT Russian patent published in 2024 - IPC C07D401/12 A61K31/506 A61P35/00 

Abstract RU 2811770 C1

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula 1, where X represents a C1-C4 alkylsulfonyl group, Y2 and Y3 each independently represents a C1-C4 alkyl group, unsubstituted or substituted with deuterium, and Y1 represents a methyl group substituted by one or more atoms of deuterium, or a pharmaceutically acceptable salt thereof. A pharmaceutical composition for the treatment of lung cancer, including the specified compound, is also proposed.

EFFECT: compound represented by Formula 1 effectively inhibits the growth of ALK-mutated and EGFR-mutated cancer cells.

7 cl, 4 dwg, 1 tbl, 8 ex

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RU 2 811 770 C1

Authors

Kim, Sung-Eun

Lee, Sunho

Rajesh, Rengasamy

Lee, Yong Hyub

Kong, Yun Jeong

Dates

2024-01-17Published

2020-12-15Filed