FIELD: pharmaceuticals.
SUBSTANCE: invention relates to the inhibition of phosphodiesterase. The following is disclosed: a method of inhibiting phosphodiesterase comprising contacting the phosphodiesterase with a compound of Formula I or a composition containing a compound of Formula I, wherein R1 is selected from either –H or –COCH3; R2 represents –H; R3 is selected from either –H or –Cl; R4 represents –H; Ar is selected from either
or
, where R5 represents –NO2; R6 represents –H; R7 is –Cl; R8 represents –H.
EFFECT: use of the invention makes it possible to effectively inhibit phosphodiesterases and may be useful in the treatment of phosphodiesterase-related disorders.
7 cl, 11 tbl, 8 ex
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