FIELD: biotechnology.
SUBSTANCE: invention relates to the production of antitumor fusion proteins, and can be used in medicine for the treatment of melanoma. The following is provided: a three-component fusion protein that is capable of binding i) PD-L1, ii) CXCR4 and iii) Fc receptor and in which component A is linked to component B and component B is linked to component C via disulphide bonds.
EFFECT: invention provides the production of a fusion protein with the possibility of multipoint molecular attachment to lead to the death, immobilization and removal of a tumour cell.
7 cl, 27 dwg, 2 tbl, 4 ex
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Authors
Dates
2024-03-14—Published
2020-01-07—Filed