MULTIFUNCTIONAL FUSION PROTEINS AND THEIR USE Russian patent published in 2024 - IPC C07K14/52 C07K14/705 C07K16/28 C07K19/00 C12N15/62 A61K38/19 A61K47/68 A61P35/00 

Abstract RU 2815388 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the production of antitumor fusion proteins, and can be used in medicine for the treatment of melanoma. The following is provided: a three-component fusion protein that is capable of binding i) PD-L1, ii) CXCR4 and iii) Fc receptor and in which component A is linked to component B and component B is linked to component C via disulphide bonds.

EFFECT: invention provides the production of a fusion protein with the possibility of multipoint molecular attachment to lead to the death, immobilization and removal of a tumour cell.

7 cl, 27 dwg, 2 tbl, 4 ex

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RU 2 815 388 C2

Authors

Tykocinski, Mark L.

Weber, Matthew C.

Smith, Carmella Romeo

Dates

2024-03-14Published

2020-01-07Filed