SCREENING OF ATTACHMENT SITES WITH FIXED POINT IN CYSTEINE-MODIFIED ANTIBODY-TOXIN (TDC) CONJUGATE Russian patent published in 2024 - IPC A61K47/68 A61P35/00 

Abstract RU 2816510 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to immunology and biotechnology. Presented is a cysteine-modified antibody-toxin conjugate having cytotoxic activity on tumour cells. Antibody contains an embedded cysteine in one or more cysteine embedding sites, which includes one or more of the positions of the constant region of the kappa/λ light chain 110, 111, 142, IgG heavy chain constant region positions 254, 255, 258, 259, 354, 355, 357, 378, 379, 386, 387 or 410 (number according to Kabat). Highly active cytotoxin is selected from MMAE, MMAF, PBD, SN-38, Dox.

EFFECT: invention enables to obtain a fixed-point antibody and a toxin and to achieve a toxin-to-antibody ratio (DAR) of 1,6 to 2 or 3,2 to 4.

8 cl, 20 dwg, 6 tbl, 21 ex

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RU 2 816 510 C2

Authors

Zhu, Yi

Wang, Yiqian

Zhuo, Shi

Li, Jie

Yu, Yongguo

Wan, Weili

Dates

2024-04-01Published

2018-06-15Filed