ANTI-CLAUDIN 18.2 ANTIBODY AND ITS ANTIBODY-DRUG CONJUGATE Russian patent published in 2024 - IPC C07K16/28 C07K16/30 C12N5/10 

FIELD: biotechnology.

SUBSTANCE: described are anti-Claudin 18.2 antibody or an antigen-binding fragment thereof, an antibody-drug conjugate for treating or preventing an oncological disease associated with Claudin 18.2 expression, an isolated polynucleotide encoding said antibody or antigen-binding fragment thereof, a nucleic acid construct for treating or preventing an oncological disease expressing Claudin 18.2, a host cell expressing anti-Claudin 18.2 antibody or an antigen-binding fragment thereof, a pharmaceutical composition for treating or preventing an oncological disease associated with Claudin 18.2 expression, a method of producing anti-Claudin 18.2 antibody or an antigen-binding fragment thereof and using the antibody or antigen-binding fragment thereof, an antibody-drug conjugate, a polynucleotide, a nucleic acid construct or a pharmaceutical composition in the manufacture of a drug for treating or preventing oncological disease expressing Claudin 18.2.

EFFECT: invention extends the range of agents binding to Claudin 18.2.

23 cl, 9 dwg, 8 tbl, 9 ex