NOVEL HUMANISED ANTIBODIES TO FACTOR XI WITH ANTITHROMBOTIC AND ANTI-INFLAMMATORY ACTION AND USE THEREOF Russian patent published in 2024 - IPC A61K39/395 C07K16/36 C12N15/13 C12N15/63 A61P7/02 

FIELD: immunology.

SUBSTANCE: disclosed is a monoclonal antibody or its antigen-binding fragment, specifically binding human factor XI or human factor XIa. Also disclosed is a polynucleotide encoding a monoclonal antibody or antigen-binding fragment, a vector, a host cell, a method of producing the monoclonal antibody or antigen-binding fragment, compositions, methods and kit using monoclonal antibody or its antigen-binding fragment. Antibody or its antigen-binding fragment is able to bind to the A2 domain of factor XI and form an immune complex therewith, thereby disrupting the contact activation molecular complex, without affecting activity or activation of haemostatic factor XI.

EFFECT: inventions can be used for safe inhibition of thrombosis and inflammation without haemostasis disturbance.

25 cl, 10 dwg, 2 tbl