FIELD: medicine; pharmaceutics.
SUBSTANCE: group of inventions relates to a pharmaceutical composition for treating or preventing an infection or colonization caused by a protozoal agent in a subject, wherein the pharmaceutical composition contains a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof selected from a group consisting of: NCL178, NCL179, NCL180, NCL181, NCL182, NCL183, NCL184, NCL185, NCL187, NCL189, NCL193, NCL194, NCL195, NCL196, NCL197, NCL198, NCL199, NCL200, NCL201, NCL202, NCL203, NCL204, NCL205, NCL206, NCL207, NCL208, NCL209, NCL210, NCL211, NCL212, NCL213, NCL214, NCL218, NCL220, NCL221, NCL222, NCL223, NCL230, NCL238, NCL239, NCL240, NCL241, NCL242, NCL243, NCL244, NCL245, NCL246, NCL247, NCL255, NCL256, NCL262, NCL264, also relates to a medical device for treating or preventing colonization or infection caused by a protozoal agent in a subject, where said medical device contains a pharmaceutical composition and is presented in the form, selected from a group comprising a plaster, bandage, dressing or implant, and also refers to a compound selected from a list of compounds or pharmaceutically acceptable salts thereof, consisting of: 4,6-bis(2-((E)-(6-chloropyridin-3-yl)methylene)hydrazinyl)pyrimidin-2-amine (NCL238); 4,6-bis(2-((E)-pyridin-3-ylmethylene)hydrazinyl)pyrimidin-2-amine (NCL239); 4,6-bis(2-((E)-pyridin-2-ylmethylene)hydrazinyl)pyrimidin-2-amine (NCL240); 4,6-bis(2-((E)-pyridin-4-ylmethylene)hydrazinyl)pyrimidin-2-amine (NCL241); 4,6-bis(2-((E)-2,5-dihydroxybenzylidene)hydrazinyl)pyrimidine-2-aminium 2-formyl-4-hydroxyphenolate (NCL242); 4,6-bis(2-((E)-3,4-dihydroxybenzylidene)hydrazinyl)pyrimidine-2-amine (NCL243); 4,6-bis(2-((E)-2,3-dihydroxybenzylidene)hydrazinyl)pyrimidine-2-aminium 2-formyl-6-hydroxyphenolate (NCL244); 4,6-bis(2-((E)-naphthalen-1-ylmethylene)hydrazinyl)pyrimidin-2-amine (NCL245); 4,6-bis(2-((1E,2E)-3-phenylallylidene)hydrazinyl)pyrimidine-2-amine (NCL246); 4,6-bis(2-((E)-3,4,5-trihydroxybenzylidene)hydrazinyl)pyrimidine-2-amine (NCL247); 4,6-bis(2-((E)-[1,1'-biphenyl]-4-ylmethylene)hydrazinyl)pyrimidin-2-amine (NCL255); 4,6-bis(2-((E)-2,4-dihydroxybenzylidene)hydrazinyl)pyrimidine-2-amine (NCL256); 4,6-bis(2-((E)-3-phenylpropylidene)hydrazinyl)pyrimidine-2-amine (NCL262); 4,6-bis(2-((E)-naphthalen-2-ylmethylene)hydrazinyl)pyrimidin-2-amine (NCL264).
EFFECT: group of inventions provides a wider range of products in treating or preventing infection or colonization caused by a protozoal agent.
26 cl, 9 tbl, 14 ex, 13 dwg
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