FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to novel compounds of formula I or a pharmaceutically acceptable salt thereof, having cyclin-dependent kinase (CDK) inhibitor properties. In the compound of formula (I)
,
X is nitrogen, Y and Z are CH; R1 is phenyl, pyridine or pyrimidine, substituted or unsubstituted by one or more substitutes selected from a group consisting of hydroxy, amino and halogen; R2 is hydrogen; and R3 is pyrimidine, substituted or unsubstituted by one or more substitutes selected from a group consisting of C1-C6 alkyl, tetrahydropyranyl, substituted or unsubstituted C1-C6 alkyl piperidinyl, morpholino, substituted or unsubstituted C1-C6 alkyl piperazinyl, amino, C1-C6 alkylamino and halogen.
EFFECT: compounds can be used for treating or preventing neuroblastoma, glioblastoma, non-small-cell lung cancer, small-cell lung cancer or colon cancer, as well as degenerative brain disease, for example, Alzheimer's disease.
8 cl, 6 dwg, 9 tbl, 112 ex
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