FIELD: biotechnology.
SUBSTANCE: described is the use of an expression vector based on an adeno-associated virus containing a codon-optimized sequence of the AIPL1 gene SEQ ID NO: 2, to reduce the intracellular immune response when introduced into human retinal cells.
EFFECT: reduced expression of pro-inflammatory genes (IL6, IL1RAPL) and increased expression of anti-inflammatory genes (IL1RN), with stable expression of the hAIPL1 gene introduced into human retinal cells using an AAV-based viral expression vector.
2 cl, 9 dwg, 2 ex
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