FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, in particular to a peptide containing SEQ ID NO: 12, as a mitochondrial localization peptide. Present invention also relates to a nucleic acid for allotopic expression of the MT-ND4 gene, comprising a nucleotide sequence SEQ ID NO: 1 and a sequence coding a peptide according to cl. 1, as well as to an expression vector containing said nucleic acid, and its use for treating Leber's hereditary optic neuropathy.
EFFECT: present invention provides mitochondrial protein localization and reduced consequences of mitochondrial dysfunction in cells with a mitochondrial gene mutation.
11 cl, 7 dwg, 2 tbl, 1 ex
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