METHOD OF PRODUCING 4,5-DISUBSTITUTED-1,2,4-TRIAZOLE-3-THIONES Russian patent published in 2024 - IPC C07D249/08 C07D403/04 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 4,5-disubstituted-1,2,4-triazole-3-thiones, compounds of general formula I, where R₁ denotes an aryl group of general formula X_nC₆H_5-n, where X, identical or different, denotes a hydrogen or halogen atom, an alkyl group with 1 to 4 carbon atoms, an alkyloxy group with 1 to 4 carbon atoms; heteryl group selected from the group: pyridyl, quinolinyl, pyrazolyl, or a heterylalkyl group selected from the group: 1,2,4-triazol-1-ylmethyl, benzimidazol-1-ylmethyl, and R₂ denotes a hydrogen atom, an amino group, an alkyl group with 1 to 10 carbon atoms, an aryl group of general formula X_nC₆H_5-n, where X, identical or different, denote a hydrogen or halogen atom, an alkyl group with 1 to 4 carbon atoms, an alkyloxy group with 1 to 4 carbon atoms, an arylalkyl group of general formula X_nC₆H_5-n(CH₂)_m, where X, identical or different, denote a hydrogen or halogen atom, an alkyl group with 1 to 4 carbon atoms, alkyloxy group with 1 to 4 carbon atoms, aminoalkyl group of general formula NH₂(CH₂)_m, benzoylamino group of general formula (X_nC₆H_5-n)C(O)NH, where X, identical or different, denotes a hydrogen or halogen atom, an alkyl group with 1 to 4 carbon atoms, an alkyloxy group with 1 to 4 carbon atoms, n denotes integer from 0 to 5, m denotes integer from 1 to 4, , consisting in fact that 5-substituted-1,3,4-thiadiazole-2-thiones of general formula VIII are reacted with amines IX and heated at temperature from 65 to 175°C in polar proton solvents, .

EFFECT: novel method of producing 4,5-disubstituted-1,2,4-triazole-3-thiones, which is more convenient, faster and has higher output of up to 98%.

1 cl, 2 tbl, 10 ex