FIELD: organic synthesis.
SUBSTANCE: invention relates to organic synthesis and specifically to a method of producing a compound which can be used in medical practice as an agent having antiaggregation and antioxidant action. Disclosed is a method of producing 2-((1S,2R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-yl)methylsulfanyl ethanol of formula I by reacting cis-mirtanethiol with 2-bromoethanol in the presence of cesium carbonate (Cs2CO3) and tetrabutylammonium iodide (TBAI) while heating the mixture in an inert gas medium until complete consumption of cis-myrtanethiol.
EFFECT: use of the invention increases output of the target compound to 95 %.
1 cl, 2 dwg, 3 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIAGGREGANT AND ANTIOXIDANT AGENT | 2023 |
|
RU2808474C1 |
| 2-(1S,2R,5S)-6,6-DIMETHYLBICYCLO[3.1.1]HEPT-2YL]METHYL}THIONYL)ETHANOIC ACID, HAVING ANTIAGGREGANT ACTION | 2013 |
|
RU2522198C2 |
| USE OF PINANYLSULFIDE WITH METHYL MERCAPTOACETATE FRAGMENT - METHYL 2-({[(1S,2R,5S)-6,6-DIMETHYLBICYCLO[3.1.1]HEPT-2-YL]METHYL}THIO) ACETATE, AS AN AGENT WITH INHIBITORY EFFECT ON PLATELET ACTIVATION | 2015 |
|
RU2671567C2 |
| COUMARINS WITH BICYCLIC MONOTERPENE SUBSTITUTES | 2019 |
|
RU2707103C1 |
| CELLULOSE-BASED SULPHATED POLYSACCHARIDE WITH GRAFTED TERPENOPHENOL, METHOD FOR PRODUCTION THEREOF AND AGENT HAVING ANTIRADICAL, ANTIOXIDANT AND MEMBRANE-PROTECTIVE ACTIVITY | 2021 |
|
RU2767207C1 |
| CHIRAL CIS-MYRTANYLSULPHONAMIDES BASED ON (-)-β-PINENE | 2021 |
|
RU2765749C1 |
| NOVEL DERIVATIVES OF 2,6-DI-ISOBORNYL PHENOL AND METHOD OF OBTAINING THEREOF | 2012 |
|
RU2516699C2 |
| SULPHO-DERIVATIVES BASED ON BETA-PINENE AND A METHOD FOR PRODUCTION THEREOF | 2019 |
|
RU2708617C1 |
| Chiral trifluoromethylated monoterpene thioacetates and myrtenal-based thiols | 2020 |
|
RU2743302C1 |
| CHIRAL MYRTANYL SULPHONAMIDES | 2019 |
|
RU2725878C1 |
