CELLULOSE-BASED SULPHATED POLYSACCHARIDE WITH GRAFTED TERPENOPHENOL, METHOD FOR PRODUCTION THEREOF AND AGENT HAVING ANTIRADICAL, ANTIOXIDANT AND MEMBRANE-PROTECTIVE ACTIVITY Russian patent published in 2022 - IPC C08B37/00 C08B15/05 

FIELD: chemistry.

SUBSTANCE: invention relates to cellulose derivatives. Disclosed is a sulphated polysaccharide of structure I with a covalently attached fragment of 2,6-diisobornyl-4-methylphenol of structure II. And R' = structure II; X = Na⁺, (Bu)₄N⁺. Method of producing sulphated polysaccharide involves O-alkylation of free hydroxyl groups of cellulose sulphate in form of tetrabutylammonium salt of 4-bromomethyl-2,6-diisobornylphenol by dissolving tetrabutylammonium salt of cellulose sulphate in DMSO. 4-bromomethyl-2,6-diisobornylphenol, previously dissolved in DMSO, is then added to the solution, the reaction mixture is stirred at temperature of 35 °C for 6 hours in an argon atmosphere. For extraction and purification, the polymer is deposited in dioxane. Then it is separated and washed twice with dioxane, for additional purification from low-molecular components the polymer is re-precipitated from chloroform into dioxane, dried in vacuum, then dissolved in water and lyophilized. If it is necessary to obtain Na-salts of polymers from tetrabutylammonium salts, aqueous 2 % solution of tetrabutylammonium salts of the obtained polymer is eluted through a column with ion-exchange resin KU-2Na with length of 60 cm and diameter of 2 cm at rate of 1.0 ml/h. Also disclosed is the use of a sulphated polysaccharide containing fragment II from 0.3 wt. % to 5.8 wt. % as an agent having antiradical, antioxidant and membrane-protective activity, consisting in the ability to effectively protect blood cells under conditions of acute oxidative stress, as well as to protect the cardiovascular system.

EFFECT: invention is aimed at obtaining a compound with low cytotoxicity, antiradical, antioxidant and membrane-protective activity, consisting in the ability to effectively protect blood cells under conditions of acute oxidative stress.

3 cl, 7 dwg, 2 tbl, 5 ex