FIELD: chemistry.
SUBSTANCE: invention relates to biochemistry, particularly to an antibody or a fragment thereof, which specifically bind the human glucagon receptor (GCGR). Also disclosed is a polynucleotide coding said antibody; expression vector containing said polynucleotide; cell containing said vector; pharmaceutical composition containing said antibody. Disclosed is a method of producing said antibody.
EFFECT: invention makes it possible to effectively treat diseases, disorders and pathological conditions associated with high blood glucose levels.
38 cl, 7 ex, 14 tbl, 5 dwg
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