FIELD: biotechnology.
SUBSTANCE: antibody variants that specifically bind the C3 component of human complement, compositions containing such antibodies, and methods of their use are provided. Also the polynucleotides and vectors encoding antibodies and cells containing them are provided.
EFFECT: invention can be used in the treatment of eye diseases in which complement activation is involved.
31 cl, 6 dwg, 22 tbl, 13 ex
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