THIENOPYRIDINONE COMPOUNDS Russian patent published in 2024 - IPC C07D495/04 C07D519/00 A61K31/506 A61K31/5377 A61P35/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to novel thienopyridinone-based compounds, specifically to a compound of formula (I), including any tautomeric and stereochemically isomeric form thereof, where each of A₁, A₂ and A₃ is independently CH or N; C1 is hydrogen or C_1-4 alkyl; C2 is hydrogen, C_1-4alkyl, hydroxyl or C_1-4 alkoxy group; Y is a direct bond; each R^b is independently hydrogen; D is 3–12 membered heterocyclyl containing at least one heteroatom selected from N or O, where said heterocyclyl is optionally substituted with 1–2 substitutes R^c; each R^c is independently C_1-6alkyl; B is 3–12-membered carbocyclyl or 3–12-membered heterocyclyl containing at least one heteroatom selected from N or O; or its pharmaceutically acceptable salt, or its solvate. Invention also relates to a pharmaceutical formulation, to use of a compound of formula (I) for preparing a drug, to a method for preventing or treating a condition mediated by FGFR kinase.

EFFECT: obtaining compounds exhibiting FGFR kinase inhibitory activity, which can be used to prevent or treat a condition mediated by FGFR kinase.

32 cl, 2 tbl, 2 ex