QUINOLINES AS FGFR KINASE MODULATORS Russian patent published in 2017 - IPC C07D215/38 C07D401/04 C07D401/14 C07D407/14 C07D413/14 A61K31/4709 A61P35/00 

FIELD: pharmacology.

SUBSTANCE: invention related to a new quinoline derivative of formula (I), where W us -N(R³)- or -C(R^3aR^3b)-; each R² is independently selected from halogen, C_1-4alkoxy, Y is -E-D; D is phenyl or 5-6-membered monocyclic heterocyclyl, containing one or two heteroatoms selected from N or O, wherein the mentioned heterocyclyl can be optionally substituted with one group of R¹; E is a link; R¹ is hydrogen, C_1-6alkyl, hydroxyC_1-6alkyl, C_1-6alkyl which is substituted with -S(=O)₂-C_1-6alkyl, R⁶; R^3a is hydroxyl, hydroxyC_1-6alkyl, cyanoC_1-6alkyl, C_1-6alkyl which is substituted with -NR¹⁰R¹¹, C_1-6alkyl which is substituted with -C(=O)-NR¹⁰R¹¹; R^3b is hydrogen; or R^3a and R^3b are combined to obtain =O or to obtain =CH-C_0-4alkyl which is substituted with R^3c; R^3c is cyano; R³ is C_2-6alkynyl, hydroxyC_1-6alkyl, hydroxyhaloC_1-6alkyl, C_1-6alkyl which is substituted with R⁹, C_2-6alkynyl which is substituted with R⁹, C_1-6alkyl which is substituted with -NR¹⁰R¹¹; R⁶ is 6-membered monocyclic heterocyclyl, containing one O atom; R⁹ is 5- or 6-membered monocyclic heterocyclyl, containing one or two heteroatoms, seleceted from N or O, each is optionally and each is independently substituted with substitute selected from =O, C_1-4alkyl, C_1-4alkoxy, S(=O)₂-NR¹⁴R¹⁵, C_1-4alkyl which is substituted with -NH-S(=O)₂-haloC_1-4alkyl, 6-membered aromatic monocyclic heterocyclyl, containing two N atoms, wherein the mentioned heterocyclyl is optionally substituted with R¹⁶; each R¹⁰ and R¹¹ independently represent hydrogen, C_1-6alkyl, haloC_1-6alkyl; each R¹⁴ and R¹⁵ independently represent C_1-4alkyl; R¹⁶ is C_1-4alkoxy; n independently represent a whole number equal to 2, 3 or 4; as well as to its pharmaceutically acceptable salt and to any tautomeric or stereochemically isomeric form thereof. The invention also relates to pharmaceutical compositions based on compound of formula (I), application of the compound of formula (I), method for the prevention or treatment of a disease and product based on the compound of formula (I).

EFFECT: new quinoline derivatives are obtained, useful in the treatment of diseases mediated by FGFR kinase.

30 cl, 2 tbl, 35 ex