FIELD: veterinary science; pharmaceutics.
SUBSTANCE: group of inventions relates to veterinary science and pharmaceutics and discloses the use of a composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment of cognitive and/or neurobehavioral disorders in a companion animal, as well as a method of treating cognitive and/or neurobehavioral disorders, comprising administering to a companion animal in need thereof, a composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, where the cognitive and/or neurobehavioral disorder is selected from cognitive dysfunction syndrome (CDS), dysthymia, involutive depression and confusion syndrome. In general formula (I), X is selected from CO, SO2 and (CH2)n; R1 is selected from hydrogen, C1-C6 alkyl and C1-C6 alkanoyl; R2 is selected from hydrogen and C1-C6 alkyl; R3 is selected from hydrogen and C1-C5 acetyl group; and R4 is selected from a phenyl group, a phenoxy group, and 5–10 membered aryl group which is unsubstituted or substituted with one or more groups consisting of nitro, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C5 alkoxy, and C1-C5 haloalkoxy; n is integer from 1 to 5, inclusive.
EFFECT: disclosed are compositions and methods of treating neurogenerative disorders.
40 cl, 15 tbl
