FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing carbetocin in a solvated crystalline form, characterized by X-ray powder diffraction peaks at 4.83, 7.43, 9.20, 17.87, 19.60, 20.43 and 21.34 degrees 2θ (Cu-K), in which carbetocin in crystalline form is crystallized from a mixture containing carbetocin and one or more liquids, wherein the one or more liquids are a mixture of ethylene glycol and acetonitrile, by cooling the mixture containing carbetocin and one or more liquids, from 40 to 5 °C or by cyclic change of temperature of mixture containing carbetocin and one or more liquids, from 40 to 5 °C. Invention relates to a method of producing carbetocin in a solvated crystalline form, characterized by X-ray powder diffraction peaks at 4.34, 6.43, 8.66, 17.37, 19.03 and 19.39 degrees 2θ (Cu-K), in which carbetocin in crystalline form is crystallized from a mixture containing carbetocin and one or more liquids, wherein one or more liquids is an aqueous acetate buffer, by maintaining the mixture containing carbetocin and one or more liquids at a temperature of at least 15 °C for 3–100 days. Invention also relates to a method of producing carbetocin in a desolvated crystalline form, characterized by X-ray powder diffraction peaks at approximately 4.11, 4.39, 5.60, 7.45, 17.75, 19.16 and 19.45 degrees 2θ (Cu-K), involving the method according to claim 1, which includes an additional step of removing the solvent and drying carbetocin in crystalline form.
EFFECT: obtaining carbetocin in crystalline form.
8 cl, 11 dwg, 6 tbl, 5 ex
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