ACARICIDE OINTMENT BASED ON AZOMETHINE AND METHOD FOR ITS PREPARATION Russian patent published in 2024 - IPC A61K31/185 A61K9/06 A61P33/14 C07C309/32 C07C303/22 C07C303/32 

Abstract RU 2831539 C1

FIELD: chemistry; pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry, medicine and veterinary science. Disclosed acaricide ointment contains, wt.%: sodium 2,2'-(1E,1'E)-(butane-1,4-diylbis(azan-1-yl-1-ylidene))bis(methan-1-yl-1-ylidene)dibenzene sulphonate of formula I – 0.2, methyluracil – 3.0, polyethylene oxide-400 – 25.0, polyethylene oxide-1500 – 71.8. Method of producing acaricide ointment consists in fact that 0.2 wt.% of sodium 2,2'-(1E,1'E)-(butan-1,4-diylbis(azan-1-yl-1-ylidene))bis(methan-1-yl-1-ylidene)dibenzene sulphonate of formula I and 3.0 wt.% of methyluracil are taken, then 25.0 wt.% of polyethylene oxide-400 is added and stirred until complete dissolution at temperature of 60 °C, then in portions with slow stirring 71.8 wt.% of polyethylene oxide-1500 is added to the heated solution and stirred until complete dissolution, then temperature is raised to 100 °C and stirred for 30 minutes, then cooled to room temperature, prepared acaricide ointment is packaged in sterile bottles.

EFFECT: what is presented is an acaricide agent in the form of an ointment for treating parasitic diseases caused by scabies mites, and a method for preparing such an ointment.

2 cl, 7 tbl, 8 ex

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RU 2 831 539 C1

Authors

Galkina Irina Vasilevna

Khaiarov Khasan Rafaelevich

Nugumanov Aigizar Nailevich

Gerasimov Aleksandr Vladimirovich

Romanov Semen Romanovich

Gizzatullin Ramis Raziapovich

Pozdeev Oskar Kimovich

Lutfullin Minsagit Khairullovich

Bakhtiiarova Iuliia Valerevna

Dates

2024-12-09Published

2024-04-27Filed