FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing a salt of an arylaminoquinazoline-containing compound of formula 2, or a hydrate thereof. Method is carried out by reacting an arylaminoquinazoline-containing compound of formula 1, with HA in a solvent, isolating a salt of an arylaminoquinazoline-containing compound of formula 2, or a hydrate thereof, where HA is hydrochloric acid; n is 2; and reaction temperature is (40–90) °C; and the reaction solvent is selected from one or a combination of two of ethyl acetate, methanol or water. Obtained hydrate is a tetrahydrate.
EFFECT: obtaining a dihydrochloride salt of a compound of formula 2 or a hydrate thereof with high output and purity, which also have good crystalline properties, solubility and stability.
2 cl, 19 dwg, 16 tbl,
15 ex
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