FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to an isolated monoclonal antibody or antigen-binding portion thereof, which binds to the alpha subunit of the interleukin-4 receptor (IL4Rα), as well as to a bispecific molecule and a composition containing it. Also disclosed is a nucleic acid molecule coding said isolated monoclonal antibody or its antigen-binding portion.
EFFECT: invention is effective for treating an allergic disease associated with excessive IL4 and/or IL13 signalling, as well as for treating a tumour associated with increased STAT6 activation.
23 cl, 22 dwg, 10 tbl, 7 ex
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