FIELD: chemistry.
SUBSTANCE: present invention relates to organic chemistry, specifically to the technology of producing diosmin, which is used in treating chronic venous insufficiency and haemorrhoids. Method of producing diosmin involves acetylation of hesperidin, oxidation of acetylated hesperidin to acetylated diosmin with an iodine donor at temperature from 90 °C to 120 °C, boiling acetylated diosmin with an alcohol in the presence of a base in an autoclave with a reflux condenser at pressure of 5 to 8 bar. Acetylated diosmin is then deprotected to obtain diosmin by heating in the presence of a base selected from sodium, potassium or lithium hydroxide, potassium carbonate, sodium methylate or sodium ethylate, separately or in a mixture with sodium or potassium acetate. At the last stage, diosmin is successively purified by treatment with a base and an acid.
EFFECT: reduced content of impurities of 6-iododiosmin and isoroifolin in the obtained target compound and providing a technology for synthesis of diosmin without using toxic pyridine.
13 cl, 4 tbl, 14 ex
| Title |
Year |
Author |
Number |
| INTERMEDIATE COMPOUNDS AND METHODS OF OBTAINING 4-(ACETYLAMINO)-3-[(4-CHLOROPHENYL)THIO]-2-METHYL-1H-INDOLE-1-OF ACETIC ACID |
2010 |
- Ainge Debra
- Butters Michael
- Merifield Eric
- Ramakrishnan Ravi
- Rayapati Ravi Naidu
- Sharma Parhalad Ray
- Thomson Colin
|
RU2551852C2 |
| METHOD FOR PRODUCING 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS |
2017 |
- Stockman, Kenneth E.
- Whiteker, Gregory T.
- Molitor, Erich J.
- Choy, Nakyen
|
RU2744834C2 |
| SYNTHESIS OF 3-METHYL-1,2,4-THIADIAZOLE-5-CARBOHYDRAZIDE OR ITS METHYL-d DUTERATED FORM |
2019 |
- Hoveyda, Hamid
- Dutheuil, Guillaume
|
RU2804686C2 |
| METHOD OF SYNTHESIS OF 5-LIPOXYGENASE INHIBITORS HAVING DIFFERENT HETEROCYCLIC SYSTEMS |
2000 |
- Norris Timoti
- Khnehtou Megan Ehlizabet
- Lehmbert Dzhon Frehnsis
|
RU2177005C1 |
| METHOD OF IBRUTINIB PRODUCING |
2016 |
- Zhang, Xiquan
- Kong, Rui
- Liu, Xin
- Chen, Shan
- Chen, Xiaoping
- Yang, Leilei
- Zhang, Aiming
- Cheng, Xingdong
|
RU2712440C2 |
| METHOD FOR PREPARING (3S)-3-AMINO-3-PYRIDYLPROPIONIC ACID AND INTERMEDIATE SUBSTANCE |
2000 |
- Skott Lorrejn
- Villani Frehnk Dzhon Ml.
- Uolker Donal'D G.
|
RU2228929C2 |
| METHODS OF PREPARING 1,3-BENZODIOXOL HETEROCYCLIC COMPOUNDS |
2018 |
- Dal, Allan Karsten
- Bajtner, Jokhan Eriksson
- Olsen, Esben Paul Krogkh
- Metsler, Bern
|
RU2814175C2 |
| NOVEL METHOD OF PRODUCING 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID |
2006 |
- Terranova Ehrik
- Paskal' Zhan-Klod
|
RU2414449C2 |
| NEW METHOD OF SYNTHESIS OF N-ACETYL-(L)-4-CYANOPHENYLALANINE, AC-(L)-PHE-(4-CN)-OH, AND N-ACETYL-(L)-PARA-AMIDINOPHENYL- -ALANINE-CYCLOHEXYLGLYCINE-β-(3-N- METHYLPYRIDINIUM)-ALANINE, AC-(L)-PAPH-CHG-PAL-ME-(3)-β |
1996 |
|
RU2170764C2 |
| METHOD OF OBTAINING 5-( α -HALOGEN ACETYL)-8-(SUBSTITUTED OXY)-(1H)-QUINOLINE-2-ONS |
2004 |
- Loze Oliv'E
- Penn Gerkhard
- Shilling Khanspeter
|
RU2339621C2 |
