NEW METHOD OF SYNTHESIS OF N-ACETYL-(L)-4-CYANOPHENYLALANINE, AC-(L)-PHE-(4-CN)-OH, AND N-ACETYL-(L)-PARA-AMIDINOPHENYL- -ALANINE-CYCLOHEXYLGLYCINE-β-(3-N- METHYLPYRIDINIUM)-ALANINE, AC-(L)-PAPH-CHG-PAL-ME-(3)-β Russian patent published in 2001 - IPC

Abstract RU 2170764 C2

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention describes the novel method of synthesis of N-acetyl-(L)-4-cyanophenylalanine of the formula (IA) NH₂ involving the following stages: a) mixing the sufficient amount of compound of the formula (I) , sufficient amount of an aqueous solution, sufficient amount of acetonitrile and sufficient amount of subtilysine for interaction with essential amount of the compound (I) for reaction medium making; and b) broughting about pH of reactive medium to corresponding pH value at the moment of subtilysine addition and maintenance corresponding pH until reaction will be terminated to yield the compound of the formula (IA). Invention describes also method of synthesis of Ac-(L)-pAph- -Chg-Pal-Me-. Method provides effective separation of racemate. EFFECT: simplified technology, high yield of end product. 31 cl, 3 tbl, 3 ex

Similar patents RU2170764C2

Title	Year	Author	Number
INHIBITORS OF VIIA FACTOR	1999	Safar Pavel Safarova Alena Vajldguz Piter	RU2223967C2
INHIBITORS OF XA FACTOR	1995	Al'-Obejdi Fakhad Lebl Mikhal Ostrem Dzhejms A. Safar Pavel Stirandova Alena Strop Piter Val'Ser Ehrmin	RU2152954C1
PURINE L-NUCLEOSIDES, THEIR ANALOGUES AND USING	1997	Uong Guehndzhaj Tehm Robert Ehverett Devron	RU2183639C2
DERIVATIVES OF 3-ARYLTHIOINDOL-2-CARBOXAMIDES AND THEIR ANALOGUES AS INHIBITERS OF CASEIN KINASE Iε	2005	Metts Uill'Jam Artur Ml.	RU2391098C2
NOVEL COMPOUNDS AS CATHEPSIN INHIBITORS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, THEIR USING AND METHOD FOR THEIR PREPARING	2002	Graup Majkl Palmer Dzhejms T. Ehldos Dehvid Dzh. Turajratnam Sukantini	RU2316546C2
MONOCYCLIC L-NUCLEOSIDES, THEIR ANALOGUES AND USING	1997	Ramasejmi Kandasejmi Tehm Robert Ehverett Devron	RU2188828C2
AMIDES OF 3-SUBSTITUTED 5- AND 6-AMINOALKYLINDOLE-2-CARBOXYLIC ACID AND RELATED ANALOGUES SUCH AS CASEIN KINASE IΕ INHIBITORS	2005	Metts Uill'Jam Artur Ml. Din Fa-Sjan	RU2369599C2
INHIBITORS OF ANTIGEN PRESENTATION BY II CLASS MHC MOLECULES AND METHODS OF APPLICATION THEREOF	2004	Olson Gehri L. Kuk Charl'Z M. Self Kristofer R.	RU2333219C2
METHOD FOR PREPARING L-AMINO ACIDS FROM RACEMIC N-ACETYL-D,L-DERIVATIVES BY ENZYMATIC CLEAVAGE	2000	Barch Klaus	RU2270869C2
DERIVATIVES OF N-(ARYLOXYALKYL)-HETEROARYLPIPERIDINE AND -HETEROARYLPIPERAZINE, INTERMEDIATE COMPOUNDS AND METHODS FOR TREATMENT OF PSYCHOSIS	1999	Strupchevski Dzhozef Tomas Khelslej Grover Kleveland Chiang Julin Bordeo Kennet Dzh.	RU2239434C2

RU 2 170 764 C2

Authors

Chi-Khsin R. King

Dates

2001-07-20—Published

1996-11-25—Filed