METHODS OF TREATING OR PREVENTING ASTHMA BY ADMINISTERING AN IL-33 ANTAGONIST Russian patent published in 2025 - IPC A61K38/17 A61K39/395 A61P11/06 

FIELD: medicine.

SUBSTANCE: presented group of inventions refers to medicine, namely to pulmonology. Disclosed is a method of treating asthma, comprising administering to a subject with blood eosinophil content exceeding 300 cells per mcl, and blood periostin level ≥74.4 ng/ml of an initial dose of 300 mg of a first antibody or an antigen-binding fragment thereof, which specifically bind IL-33, and an initial dose of 300 mg of a second antibody or an antigen-binding fragment thereof, which specifically bind IL-4R once every two weeks. What is presented is a method of treating moderate to severe asthma involving administering 300 mg of SAR440340 and 300 mg of dupilumab subcutaneously once every two weeks. Disclosed is a method for reducing an inhaled corticosteroid (ICS) dependence and long-acting β2-adrenergic agonist (LABA) in a patient with asthma.

EFFECT: presented group of inventions provides reduced loss of asthma control due to a combination therapy with an IL-33 antibody and an IL-4R antibody.

16 cl, 134 dwg, 19 tbl, 2 ex