FIELD: biotechnology.
SUBSTANCE: disclosed are: recombinant antigen-binding proteins specifically binding to nerve growth factor (NGF), a method for production thereof, nucleic acid coding said proteins, a veterinary composition for treating diseases associated with high levels of NGF, an expression vector containing the recovered nucleic acid. Also disclosed is a host cell containing a vector for producing an antigen-binding protein and a host cell containing a nucleic acid for producing an antigen-binding protein, a method of treating a disorder associated with high NGF levels in a subject, and a method of inhibiting NGF activity in a subject, comprising administering a pharmaceutical composition to said subject.
EFFECT: invention can be used for treating a disorder associated with high levels of NGF.
37 cl, 16 dwg, 5 tbl, 14 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTI-CANINE CTLA-4 ANTIBODY | 2020 |
|
RU2818586C2 |
| ANTIBODIES TO DOGS' PD-1 | 2014 |
|
RU2732604C2 |
| MONOCLONAL ANTIBODIES TO INTERLEUKIN-31 FOR VETERINARY USE | 2019 |
|
RU2795411C2 |
| CANINIZED ANTI-HUMAN CTLA-4 ANTIBODIES | 2020 |
|
RU2822460C2 |
| CANINE ALPHA INTERLEUKIN-4 RECEPTOR ANTIBODIES | 2020 |
|
RU2840044C1 |
| CANINE ALPHA INTERLEUKIN-4 RECEPTOR ANTIBODIES | 2020 |
|
RU2838943C1 |
| DOG ANTIBODIES WITH MODIFIED CH-CH SEQUENCES | 2014 |
|
RU2815059C2 |
| DOG ANTIBODIES WITH MODIFIED CH2-CH3 SEQUENCES | 2014 |
|
RU2801209C2 |
| ANTI-IL31 ANTIBODIES FOR USE IN VETERINARY SCIENCE | 2020 |
|
RU2835543C1 |
| ANTI-IL31 ANTIBODIES FOR VETERINARY USE | 2018 |
|
RU2795485C2 |
