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RU

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2 838 538

(13)

C1

(51)

IPC

A61K31/522(2006-01-01)

A61P1/16(2006-01-01)

C07D473/24(2006-01-01)

(21) (22)

Application

2021118928, 2017-08-28

(24)

Start date

2017-08-28

(22)

Actual filing date

2017-08-28

(45)

Published

2025-04-18

(72)

Inventor

Gao, LuLiang, ChungenYun, HongyingZheng, XiufangWang, JianpingMiao, KunZhang, Bo

(73)

Holder

F. Hoffmann-La Roche Ag

7-SUBSTITUTED SULPHONIMIDOYLPURINONES FOR TREATING AND PREVENTING VIRAL INFECTION Russian patent published in 2025 - IPC A61K31/522 A61P1/16 C07D473/24 

Abstract RU 2838538 C1

FIELD: chemistry.

SUBSTANCE: present invention relates to a method for stimulating production of HBV-specific antibodies using a compound selected from: 6-amino-9-benzyl-N-methyl-8-oxo-N-propyl-2-(propylsulphonimidoyl)purine-7-carboxamide, 6-amino-9-[(4-chlorophenyl)methyl]-2-[S(R)-ethylsulphonimidoyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide, 6-amino-9-[(4-chlorophenyl)methyl]-2-[S(S)-ethylsulphonimidoyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide, 6-amino-9-[(4-chlorophenyl)methyl]-N-ethyl-2-[S(S)-ethylsulfonimidoyl]-N-methyl-8-oxo-purine-7-carboxamide, 6-amino-9-[(4-chlorophenyl)methyl]-N-ethyl-2-[S(R)-ethylsulphonimidoyl]-N-methyl-8-oxo-purine-7-carboxamide, 6-amino-2-[S(R)-ethylsulphonimidoyl]-N-methyl-8-oxo-N-propyl-9-(p-tolylmethyl)purine-7-carboxamide, 6-amino-2-[S(S)-ethylsulphonimidoyl]-N-methyl-8-oxo-N-propyl-9-(p-tolylmethyl)purine-7-carboxamide, 6-amino-N-ethyl-2-[S(S)-ethylsulphonimdoyl]-N-methyl-8-oxo-9-(p-tolylmethyl)purine-7-carboxamide, 6-amino-N-ethyl-2-[S(R)-ethylsulphonimidoyl]-N-methyl-8-oxo-9-(p-tolylmethyl)purine-7-carboxamide, 6-amino-2-(ethylsulphonimidoyl)-9-[(4-fluorophenyl)methyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide, 6-amino-2-[S(R)-ethylsulphonimidoyl]-9-[(4-fluorophenyl)methyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide, 6-amino-2-[S(S)-ethylsulphonimidoyl]-9-[(4-fluorophenyl)methyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide, 6-amino-9-[(4-bromophenyl)methyl]-2-(ethylsulphonimidoyl)-N-methyl-8-oxo-N-propyl-purine-7-carboxamide, 6-amino-2-[S(R)-ethylsulphonimidoyl]-9-[(4-bromophenyl)methyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide, 6-amino-2-[S(S)-ethylsulphonimidoyl]-9-[(4-bromophenyl)methyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide, 6-amino-9-[(4-bromophenyl)methyl]-N-ethyl-2-(ethylsulphonimidoyl)-N-methyl-8-oxo-purine-7-carboxamide, 6-amino-9-[(4-bromophenyl)methyl]-N-ethyl-2-[S(S)-(ethylsulphonimidoyl)]-N-methyl-8-oxo-purine-7-carboxamide, 6-amino-9-[(4-bromophenyl)methyl]-N-ethyl-2-[S(R)-(ethylsulphonimidoyl)]-N-methyl-8-oxo-purine-7-carboxamide or pharmaceutically acceptable salts thereof, enantiomers or diastereomers.

EFFECT: invention provides stimulation of production of HBV-specific antibodies.

1 cl, 7 dwg, 14 tbl, 57 ex

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RU 2 838 538 C1

Authors

Gao, Lu

Liang, Chungen

Yun, Hongying

Zheng, Xiufang

Wang, Jianping

Miao, Kun

Zhang, Bo

Dates

2025-04-18—Published

2017-08-28—Filed

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