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(21) (22)

Application

4165150/04, 1986-12-22

(22)

Actual filing date

1986-12-22

(45)

Published

1996-06-10

(72)

Inventor

Mirskova A.N.Guseva S.A.Levkovskaja G.G.Tizenberg G.M.Suslova S.K.Kuz'Mina L.A.Voronkov M.G.Miroshnikov F.F.

PARA-CHLOROPHENYLSULFONYLACETIC ACID TRIS-(2-HYDROXYETHYL)-AMMONIUM SALT SHOWING HYPOCHOLESTEROLEMIC ACTION Russian patent published in 1996 - IPC

Abstract SU 1417426 A1

FIELD: organic chemistry, medicine. SUBSTANCE: product: p-chlorophenylsulfonylacetic acid tris-(2-hydroxyethyl)-ammonium salt. Synthesis is carried out from p-chlorophenylsulfonylacetic acid and triethanolamine in ethanol medium at boiling. Yield is 90%, m. p. is 92-93 C, empirical formula is C14H22ClNO7S. Activity of product exceeds that of clofibrate, toxicity LD50 = 6000 ± 108 mg/kg (intaperitoneally), active dose 25 mg/kg decreases cholesterol level in blood by 53.5% as compared with control value. Synthesized compound can be used for prophylaxis and treatment of atherosclerosis. EFFECT: enhanced effectiveness, high yield. 3 tbl

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SU 1 417 426 A1

Authors

Mirskova A.N.

Guseva S.A.

Levkovskaja G.G.

Tizenberg G.M.

Suslova S.K.

Kuz'Mina L.A.

Voronkov M.G.

Miroshnikov F.F.

Dates

1996-06-10—Published

1986-12-22—Filed

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