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Application

4145548/04, 1986-11-10

(22)

Actual filing date

1986-11-10

(45)

Published

1994-03-15

(72)

Inventor

Dorokhova E.M.Zolotarev Ju.A.Kozik V.S.Mjasoedov N.F.

(73)

Holder

Institut Molekuljarnoj Genetiki Ran

METHOD OF SYNTHESIS OF PROLINE HIGH-LABELED WITH TRITIUM Russian patent published in 1994 - IPC

Abstract SU 1432968 A3

FIELD: organic chemistry, amino acids. SUBSTANCE: proline is synthesized by reduction of 2-pyrrolcarboxylic acid on heterogeneous palladium catalyst in the presence of Pt or Ph at 100-160 C. Method ensures to prepare high-labeled proline containing up to six tritium atoms in molecule. As a result, molar radioactivity of proline is increased from 58 Ku/mmole (in known method) to 132-183 Ku/mmole. EFFECT: enhanced molar radioactivity of product. 1 tbl

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SU 1 432 968 A3

Authors

Dorokhova E.M.

Zolotarev Ju.A.

Kozik V.S.

Mjasoedov N.F.

Dates

1994-03-15—Published

1986-11-10—Filed

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